Antifertility and Estrogenic Activity of Seeds of Datura alba in Female Albino Rats

Abstract

To evaluate the effect of acetone and ethanol of Datura alba seed on estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats. Plant extracts were tested for their effect on the estrous cycle of two dose levels: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity. The acetone and ethanol extracts were most effective in interrupting the normal estrous cycle of the rats (P<0.05, P<0.01, P<0.001). These later exhibited prolonged diestrous stage of the estrous cycle with consequent temporary inhibition of ovulation. The antiovulatory activity was reversible on discontinuation of treatment. Both the extracts showed significant estrogenic and antiestrogenic activity.