Simultaneous Estimation of Ribociclib and Letrozole in Pure and Pharmaceutical Dosage Form by validated UV- VIS Spectroscopy Method

Abstract

A simultaneous UV-Visible spectrophotometric method was developed for Ribociclib and Letrozole. Both drugs showed linearity in the range of 2–10 μg/ml with correlation coefficients 0.9997 and 0.9998. Precision studies revealed %RSD < 2% for repeatability, intra-day, and inter-day precision. Accuracy results showed recoveries of 100.29% for Ribociclib and 101.16% for Letrozole, within acceptance limits (98–102%). The assay of marketed formulation confirmed values within the specification range (98–102%). LOD/LOQ values were low, confirming high sensitivity.