Fast dissolving Buccal film: A comprehensive Review

Abstract

Fast dissolving buccal films (FDBFs) have emerged as a promising drug delivery system, offering advantages such as ease of administration, improved patient compliance, rapid drug dissolution, and potential for enhanced bioavailability. This abstract provides an overview of the future prospects of FDBFs based on ongoing research and development in the field. Future advancements in FDBFs involve improved formulation techniques, including the exploration of different polymers, excipients, and additives to optimize film integrity, drug release, and mucoadhesive properties. Additionally, the integration of nanotechnology in FDBFs is being investigated, with a focus on nanostructured films and nanocarriers to enhance drug solubility, stability, and permeability. Combination therapies within FDBFs are anticipated, allowing for the simultaneous or sequential delivery of multiple drugs, enabling personalized treatment regimens. Targeted and controlled drug delivery mechanisms, such as the incorporation of targeting ligands or stimuli-responsive systems, are being explored to achieve site-specific drug release. Furthermore, the inclusion of theranostic capabilities in FDBFs, combining therapeutic agents with diagnostic functionalities, holds promise for real-time monitoring of drug release, drug localization, and disease response. Patient-centric design considerations, including taste masking, ease of administration, and aesthetic appeal, are expected to drive future developments in FDBFs, particularly for paediatric and geriatric populations. The integration of FDBFs with digital health technologies, such as smart sensors or electronic monitoring systems, is also anticipated to revolutionize medication management and enable personalized therapy. Overall, the future of fast dissolving buccal films is promising, with ongoing research and development focused on improving formulation techniques, expanding applications, and incorporating novel technologies. These advancements have the potential to enhance drug delivery efficacy, patient compliance, and personalized therapy, ultimately improving patient outcomes.