To study the prevalence of adverse drug reactions (ADRs) in various departments of tertiary care hospital

Abstract

Introduction :An ADR is defined by the World Health Organization (WHO) as: ‘a response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function’.1 Each year, millions of patients experience ADRs, especially with the increased use of medicinal drugs. ADRs take the place as the fourth to sixth major cause of death, eclipsing pulmonary disease, diabetes, acquired immunodeficiency syndrome and pneumonia. According to the Centers for Disease Control and Prevention, ADRs are responsible for almost 1,300,000 emergency department visits annually.Method: A spontaneous reporting technique was followed. Patients were selected in the medical ward. We attended ward rounds and encouraged the doctors to report suspected (ADEs) as well as nurses, pharmacist, patient and their care taker. All the in-patients who assessed for ADR’s during the study period are check their past medication history. Patient was selected from general medicine department according to the inclusion and exclusion criteria of WHO. Result And Discussion: During the study period total 6930 patients case sheets were reviewed among them 540 (07.79%) patients have experienced at least one adverse drug reaction (ADR). Out of 540 patients are divided into two groups 212 (39.25%) experienced 265 ADRs and admitted in hospital. In the age group 31-40 maximum ADRs was found. It also have seen male patient of all age group have more ADRs, and most ADRs. Study also soonest1 ADRs, Conclusion: The study show that ADRs Are the main cause of increase of medication cost which may be reduced by establishing of proper ADRs monitor center and establishing ADRs information center and their collaboration with other agencies.