FDA-Approved Natural Disintrgrant for Fast Dissolving Tablets
Keywords:Oral-disintegrants tablets, gums, mucilages.
Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate of dosage form. Diverse categories of super-disintegrants are such as synthetic, semi-synthetic, natural and co-processed blends etc. These have been employed to develop effectual ODTs and to overcome the limitations of conventional tablet dosage forms. The plant derived natural super disintegrants comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified into more polar form. This review discuss about the development of various kind of natural super-disintegrating agents, along with their role in the tablet disintegration and as potent candidate to be used in ODTs, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance.
Ansel HC, Popvich NG, Allen LV. Pharmaceutical Dosage Forms and Drug Delivery System. 1st ed. United States: Lippincott Williams and
Jain NK, Sharma SN. A Text Book of Professional Pharmacy. 4th ed. New Delhi: Vallabh; 1998.
Yadav ND, Pingale PL, Tatane SR. Comparative study on effect of natural and artificial superdisintegrants in the formulation of fast
dissolving aspirin tablet. J Pharm Res 2010;3:1594-7.
Abdulraheman ZS, Patel MR, Patel KR. A review on immediate release tablet. Int J Univ Pharm Biol Sci 2014;3:93-113.
Ratanaparkhi PM, Mohanta GP, Upadhyay L. Review on fast dissolving tablets. J Pharm Res 2009;2:5-12.
Pahwa R, Piplani M, Sharma PC, Kaushik D, Nanda S. Orally disintegrating tablets-friendly to pediatrics and geriatrics. Arch Appl Sci Res 2010;2:35-48.
Deshmukh KR, Vidyanand P, Shekhar V, Kumar PA, Dewangan P. A review on mouth dissolving tablet techniques. Int J Res Ayurveda
Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: A novel approach to drug delivery. Int J Curr Pharm Res 2011;1:1-7.
Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules 2009;14:2602-20.
Kumar SA, Vivek D, Vandana A. Role of natural polymers used in floating drug delivery system. J Pharm Sci Innov 2012;1:11-5.
Bruscato FN, Danti AG. Pharmaceutical Tablets Containing Chitin or Chitosan as a Disintegrant, US Patent No. 4, 086, 335; 1978.
Batham P, Kalichaman SG, Osborne BE. A 52-week oral toxicity study of Gellan gum in the Beagle dog. In: Unpublished Project 81779, WHO
by Kelco (Divison of Merck & Co. Inc.), San Diego, Calif, USA. Montreal, Canada: Bio Research Lab. Ltd.; 1986.
Shirwaikar A, Shirwaikar A, Prabhu S, Kumar G. Herbal excipients in novel drug delivery systems. Indian J Pharm Sci 2008;70:415-22.
Setia A, Goyal N, Kansal S. Formulation and evaluation of ciprofloxacin hydrochloride dispersible tablets using natural substances as
disintegrates. Pelagia Res Libr Pharm Sin 2011;2:36-9.
Kumar R, Patil S, Patil MB, Patil SR, Paschapur MS. Isolation and evaluation of dis-integrant properties of fenugreek seed mucilage. Int J PharmTech Res 2009;1:982-96.
Halakatti KP, Omer S, Gulgannavar SR, Kumar PP. Formulation and evaluation of mouth disintegrating tablets of famotidine by using Hibiscus ros sinensis mucilage and treated agar. Int J Res Ayurveda Pharm 2010;1:497-505.
Rinaudo M. Chitin and chitosan: Properties and applications. Progress Polym Sci 2006;31:603-32.
Antony PJ, Sanghavi NM. A new dis-integrant for pharmaceutical dosage forms. Drug Dev Ind Pharm 1997;23:41-5.
Malviya R, Srivastava P, Kulkarni GT. Application of Mucilage’s and drug delivery: A review. Adv Biol Res 2011;5:1-7.
Liebermann HA, Lachman L, Schawstr JB. Pharmaceutical Dosage Forms Tablets. Vol. 2. New York: Marcel Dekker; 1989.
Mehta KK, Patel HH, Patel ND, Vora CN, Patel NJ. Comparative evaluation of natural and synthetic superdisintegrant for promoting
nimesulide dissolution for fast dissolving technology. Int J Pharm Pharm Sci 2010;2:102-8.
Singh BS. Pysllium as therapeutic and drug delivery agent. Int J Pharm 2007;334:1-14.
Ghenge GG, Pande SD, Ahmad A, Jejurkar L, Birari T. Development and characterization of fast disintegrating tablet of amlodipine besylate
using mucilage of Plantago ovata as a natural superdisintegrant. Int J PharmTech Res 2011;3:938-45.
Kulkarni U, Rao NG. Design and development of aceclofenac fast dissolving tablets by amorphous solid dispersion technique using
modified Marmelos gum. Int J Pharm Res Dev 2011;3:201-10.
Malik K, Arora G, Singh I. Locust bean gum as superdisintegrantformulation and evaluation of nimesulide orodispersible tablets. Polimery Med 2011;41:17-28.
Ahad HA, Sreenivsulu R, Reddy KK, Kavitha K, Sumapadmaja B, Reddy VK. Isolation and characterization of Ficus indica fruit mucilage.
J Pharm Res 2011;4:726-7.
Nayak RK, Patil SR, Patil BM, Mahalaxami B. Evaluation of disintegrating properties of Mangifera indica gum. RGUHS J Pharm Sci 2011;1:11-21.
Prabakaran L, Sendhil D. Formulation development of patient friendly dosage form: All in one natural excipient as binder, diluent and disintegrant. Int J Pharm Pharm Sci 2011;3 Suppl 2:97-102.
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